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InicioE-BooksE-Books Médicos Immunodeficiency
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Immunogenomics And Human Disease

Immunodeficiency

Publisher: InTeOp | 2012 | ISBN-13: 9789535107910 | 401 Pages | PDF | 8,5 MB


This book reflects a major medical problem which is still under thorough studies. The book has an international team of authors all contributing to the investigation of the questions of what, why, how, when and where the immune system deviates from its normal function, what clinical consequences are manifested and is there a way to prevent and treat the immunodeficiency cases.

In 1968, hematopoietic stem cell transplantation (HSCT) was first performed for patients with inherited cellular immunodeficiencies: a child with severe combined immune deficiency (SCID) and another with Wiskott–Aldrich syndrome (WAS) transplanted from matched siblings [1, 2]. Since then, HSCT techniques have advanced enormously due to refined HLA-tissue typing, the increased use of alternative donors, the availability of new stem cell sources including umbilical cord blood as well as less toxic chemotherapeutic conditioning [3], and graft-versus host disease (GVHD) prophylaxis. Supportive care has also improved, with molecular detection of viral infection enabling pre-emptive antiviral treatment before organ damage supervenes [4].

Greater awareness of primary immunodeficiency (PID) amongst general paediatricians, highlighted by campaigns promoting warning signs has lead to earlier diagnosis and referral to specialist centres[5]. Indications for HSCT increase as advances in molecular immunology better define PIDs while parallel studies of the natural history of PIDs reveal which will benefit most from early HSCT before organ damage is present[6]. There are now nearly 200 molecularly defined PIDs. HSCT aims to give stable donor stem cell engraftment after partial or full ablation of the recipient’s marrow and immune system using a combination of chemotherapy, antibody therapy, and a graft-versus-marrow effect. [7]

Nearly 1,500 children in Europe who have received allogeneic HSCT for PIDs[8] were reported recently, as well as over 1,000 children from Northern America in 2008.[9] Overall survival has increased to 90% for SCID babies with a genoidentical donor and nearly 70% for those given matched unrelated donor (URD) HSCT. For non-SCID PIDs, the survival for both genoidentical and URD HSCT is between 70% and 80%.[8] Together with improved survival advances have led, and continue to focus on, improved quality of life longterm.

Categoría: E-Books Médicos Etiquetas: Alergia e Inmunología, Células Madre - Stem Cells, Genética
  • Descripción
Descripción

The theme of the Book “Immunodeficiency” is to emphasize the need to understand the basic immunologic, biologic, biochemical, metabolic, microbiologic, viral and clinical pathways which serve as the basis for the identification procedures used to investigate the major topic: the immune system, its alterations and clinical impact on humans and animals.

The authors perform a thorough analysis and updated approaches to reveal the immunodeficiency in various directions, thus helping the readers to deepen their knowledge on its practical issues.

Because of limitations of space, not all areas in clinical and experimental immunology, associated to the discussed problem, could be included in this Book.

Immunology, in particular immunopathology and immunodeficiency, is a subject too broad to introduce as a full picture here. However, the selected chapters and sections of the Book allow the specialized audience to find a logical, step-by-step approach to the recovery and medically important conclusions and definitions of different immunodeficiency states, which is the hallmark of this text. Experimental, laboratory and clinical correlations and discussions of the results have been expanded, both because we believe all interested readers, students, interns, post-docs, residents, specialists, advanced researchers in all corresponding specialities, even other than those directly involved, can profit from the use of this Book and because biomedical technologists have expressed much interest in knowing more about the disease processes caused by the pathologic alterations of the immune system, specifically the immunodeficiency.

We wish to acknowledge all authors who provided their scientific and practical achievements for the benefit of the modern immunopathology.

Prof. Dr. Krassimir Metodiev
MD, PhD, DScmed, President of IMAB,
Secretary General of FESCI, Head of the Department of Immunology,
Medical University, Varna,
Bulgaria

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