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InicioE-BooksE-Books Médicos Immunogenomics And Human Disease
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Immunology: A Short Course

Immunogenomics And Human Disease

Detalles del producto

  • Tapa dura: 548 páginas
  • Editor: Wiley John + Sons; Edición: 1 (2 de diciembre de 2005)
  • Idioma: Inglés
  • ISBN-10: 0470015306
  • ISBN-13: 978-0470015308

 

This book provides an overview of key conceptual and molecular technologies being deployed in immunogenomics, followed by detailed evaluations of the impact of genomics and systems biology on important areas such as cancer immunology, autoimmunity, allergy and the response to infection.

One of the major features that distinguishes vertebrates from invertebrates is the presence of a complex immune system. Over millions of years, many novel immune genes and gene families have emerged and their products form sophisticated pathways conferring protection against most pathogens. The Human Genome Project revealed that the immunoglobulin gene superfamily was one of the largest in the genome, containing more than 2% of all known human genes. High-throughput technologies for the study of DNA, mRNA and proteins, such as microarrays and real-time gene amplification technologies, as well as biobank facilities, are enabling the investigation of these genes and pathways in ever more detail. The parallel development of databases and bioinformatics tools to store and interpret this information will also contribute to greater understanding of the function of the immune system.

Genomics is finally changing from an academic discipline to one with real clinical relevance. The study of immune regulation in response to pathogen invasion, to the presence of malignant or allogeneic tissue and, in some cases, to normal autologous tissue requires techniques that study the behaviour of whole systems in parallel. A genome-wide, systems biology approach is needed to understand the genetic and environmental factors that regulate the healthy immune system and its response to pathogens as well as to malignant cells arising within the body. It will also facilitate determining what goes wrong when the immune system attacks normal host cells, as in autoimmune diseases such as Type 1 diabetes.

Finally, greater knowledge of the immune system will enable us to use it to promote health and cure disease, through vaccine development – targeting both pathogens and tumour cells – and by manipulation of cellular and humoral defences.

This book provides an overview of key conceptual and molecular technologies being deployed in immunogenomics, followed by detailed evaluations of the impact of genomics and systems biology on important areas such as cancer immunology, autoimmunity, allergy and the response to infection. It will be of interest to all those working in immunology, as well as to bioinformaticians and specialists such as oncologists and microbiologists.

Categoría: E-Books Médicos Etiquetas: Alergia e Inmunología, Genética, Oncología
  • Descripción
  • Por qué utilizar archivos PDF
Descripción

The global immunogenomics approach stands on three foundations: (i) the revolutionary expansion of genome knowledge that is now available in giant computer databanks; (ii) robust nanotechnology such as microarray chips and similar tools that allow real-time measurement of gene variants and gene expression; and (iii) the availability of improved techniques in immune bioinformatics (‘immunomics’) that could generate data-mining tools for efficient interpretation of otherwise unmanageable biological information.

Given the complexity of the immune system network and the multidimensionality in clinical situations, such as tumour–host interactions, autoimmune and allergic disfunctions, the comprehension of immunology should benefit greatly from highthroughput DNA array analysis, which can portray the molecular kinetics of an immune response on a genome-wide scale. This will accelerate the accumulation of knowledge and ultimately catalyse the development of new hypotheses in cell biology. Although in its infancy, the implementation of DNA array technology in basic and clinical immunology studies has already provided investigators with novel data and intriguing hypotheses concerning the cascade of molecular events that leads to an effective immune response in diseased tissue.

Recent trends in immunology focus on immunological databases, antigen processing and presentation, immunogenomics, host–pathogen interactions and mathematical modelling of the immune system. Immunogenomics represents one of the first stages in the systems biology era in immunology. Computational analysis is already becoming an essential element of immunology research, particularly in the management and analysis of immunological data.

On the basis of the individual chapters in this book, I foresee the emergence of immunomics not only as a collective endeavour by researchers to decipher the sequences of T cell receptors, immunoglobulins and other immune receptors, but also to functionally annotate the capacity of the immune system to interact with the whole array of self and non-self entities, including genome-to-genome interactions.

Andra´s Falus
Budapest, June, 2005

Por qué utilizar archivos PDF

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Eva Solo
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