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InicioE-BooksE-Books Médicos Monoclonal Antibodies: Methods and Protocols
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Monoclonal Antibodies: Methods and Protocols

Product details

  • Series: Methods in Molecular Biology (1131) (Book 1131)
  • Paperback: 589 pages
  • Publisher: Humana; Softcover reprint of the original 2nd ed. 2014 edition (August 23, 2016)
  • Language: English
  • ISBN-10: 1493963228
  • ISBN-13: 978-1493963225
  • Product Dimensions: 7 x 1.2 x 10 inches
  • Shipping Weight: 3.3 pounds

 

Monoclonal Antibodies: Methods and Protocols, Second Edition expands upon the previous edition with current, detailed modern approaches to isolate and characterize monoclonal antibodies against carefully selected epitopes. This edition includes new chapters covering the key steps to generate high quality monoclonals via different methods, from antigen generation to epitope mapping and quality control of the purified IgG. Chapters are divided into four parts corresponding to four distinct objectives. Part I covers monoclonal antibody generation, Part II deals with monoclonal antibody expression and purification, Part III presents methods for monoclonal antibody characterization and modification, and Part IV describes selected applications of monoclonal antibodies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Categoría: E-Books Médicos Etiqueta: Alergia e Inmunología
  • Descripción
  • Por qué utilizar archivos PDF
Descripción

Over the past decades, monoclonal antibodies (monoclonals) have become invaluable for basic research, diagnostics, clinicians, and thousands of patients suffering from severe afflictions. Monoclonals are widely used laboratory reagents, and it is fair to say that the availability of a good monoclonal has led to increased understanding of the target biology as many experimental approaches, ranging from classical western blots to chromatin immnunoprecipitation assays, are enabled. Beyond basic research, therapeutic monoclonals are increasingly used as drugs and will account for over 50 billion USD in sales in 2013, and this fi gure is forecast to grow at double-digit rate, higher than any other therapeutic class. Since OKT3 (Muromonab-CD3, Johnson & Jonson/Ortho Biotech), the fi rst monoclonal approved for human use, 34 other monoclonals have been approved.

This is the tip of the iceberg, as it is estimated that over 400 monoclonals are in clinical development worldwide. This brisk success is explained by several factors. First and most importantly, their specificity and low off-target toxicity often provide monoclonals with an exceptional “therapeutic window,” i.e., the ability to dose them effectively with acceptable side effects. Monoclonals are also embraced because of their prolonged half-life and, more generally, as their pharmacokinetic properties are more predictable than for other classes of drugs. Consequently, the rate of success for the clinical development of monoclonals is signifi cantly higher than for small molecule drugs or for other biologicals.

With the progress of genetic and protein engineering, academic labs and the biopharmaceutical industry have advanced many novel antibody formats and antibody-based approaches. These comprise multi-specifi c antibodies, fragments, antibody–drug conjugates, antibodies with enhanced effector function, and so on. However, despite these evolutions, being able to generate high-quality monoclonals against carefully selected epitopes remains the absolute foundation for subsequent improvements. Equally important is the meticulous characterization of candidate monoclonals. We actually contend that because of the greatly expanded toolkit for improving monoclonals, epitope selection and biochemical characterization has now become even more important for generating well-differentiated monoclonals. One can directly witness this notion at the bench with antibodies raised against the same target that perform very differently in various assays but also in the clinic, where monoclonals against different epitopes can exert very different responses in patients (e.g., the three anti-CD20 monoclonals Rituximab, Ofatumumb, and GA-101 by Roche, Genmab/GSK, and Roche respectively).

Por qué utilizar archivos PDF

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