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InicioOtros The Age of Genomes – Tales from the Front Lines of Genetic Medicine
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Techlife News - May 2020

The Age of Genomes – Tales from the Front Lines of Genetic Medicine

Detalles del producto

  • Pasta blanda: 244 páginas
  • Editor: Beacon Press; Edición: Reprint (16 de mayo de 2017)
  • Idioma: Inglés
  • ISBN-10: 080700877X
  • ISBN-13: 978-0807008775
  • Dimensiones del producto: 15.2 x 1.8 x 23.1 cm
  • Peso del envío: 381 g

A leading geneticist explores what promises to be one of the most transformative advances in health and medicine in history

Almost every week, another exciting headline appears about new advances in the field of genetics. Genetic testing is experiencing the kind of exponential growth once seen with the birth of the Internet, while the plummeting cost of DNA sequencing makes it increasingly accessible for individuals and families.

Steven Lipkin and Jon Luoma posit that today’s genomics is like the last century’s nuclear physics: a powerful tool for good if used correctly, but potentially dangerous nonetheless. DNA testing is likely the most exciting advance in a long time for treating serious disease, but sequencing errors, complex biology, and problems properly interpreting genetic data can also cause life-threatening misdiagnoses of patients with debilitating and fatal genetic diseases. DNA testing can also lead to unnecessary procedures and significantly higher health-care costs. And just around the corner is the ability to cure genetic diseases using powerful gene-editing technologies that are already being used in human embryo research. Welcome to the Age of Genomes!

The Age of Genomes immerses readers in true stories of patients on the frontier of genomic medicine and explores both the transformative potential and risks of genetic technology. It will inform anxious parents increasingly bombarded by offers of costly new prenatal testing products, and demonstrate how genetic technology, when deployed properly, can significantly improve the lives of patients who have devastating neurological diseases, cancer, and other maladies. Dr. Lipkin explains the science in depth, but in terms a layperson can follow.

Categoría: Otros Etiquetas: Genética, Genoma
  • Descripción
  • Por qué utilizar archivos PDF
Descripción

In each of our beginnings was our personal genome, created when we were less than a single cell and with us every moment since. Our genome has helped define what we have, and haven’t, done with our lives. This precise DNA barcode, because of its enormous length and complexity, distinguishes each of us not only from the other eight billion people alive today on the planet, but also from each and every other of the twenty-something billion human beings who have ever lived since the dawn of humanity two hundred thousand years ago. Indeed, distinguishing each of us from every other living organism, whether flora, fauna, virus, or archebacteria for the past four billion years. What could be more personal than that?

Even when it’s hot outside, we don’t walk around naked. People are typically squeamish about public nudity because they don’t want every detail of their reproductive anatomy put out on display for all the world to see, and prudence prevails. But this particular modesty only runs skin deep. What is more profoundly revealing than being naked in a crowd? Today, certainly one answer to this question, mechanistically more than skin deep and down to the core of our very being, is the sequence of our very own genome. However, even if we generally don’t like getting naked in public, we will when there’s a good reason to do so. One place people typically do this is their doctor’s office. We bare ourselves despite that slightly awkward feeling we have waiting there, exposed on the usually cold examining table, to allow our doctor to see our most intimate parts because we know this can help keep us healthy and so it’s worth the discomfort. Conversely, hiding some of these parts and refusing a doctor’s examination could cause a lot of pain, or worse, in the end. This is essentially the same reason why people decide to share this intimacy in silico by giving their personal genome information to their doctor. Such information provides a tool to help navigate us to a healthy one hundred and fifty years or so of  life. This is not astrology: this is bona fide biological science. But what does it all
add up to?

Biografía del autor

Steven Monroe Lipkin, MD, PhD, FACMG, has been a practicing clinical geneticist for almost twenty years. He directs the Adult and Cancer Genetics Clinic and is the vice chair for Translational Research at the Sanford I. and Joan Weill Department of Medicine at Weill Cornell in New York City.

Jon R. Luoma‘s writing about science and the environment has appeared in National Geographic, GQ, the New York Times Sunday Magazine, and Audubon, where he was a longtime contributing editor. He is the author of three previous nonfiction books: The Hidden Forest, A Crowded Ark, and Troubled Skies, Troubled Waters.

Por qué utilizar archivos PDF

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